| Event Type | Date | Place | Individual | Documents |
| Death | 1 January 1680 | Medfield, Ma. | Joseph CLARK |
| Birth | 2 January 1680 | R.I. | Joanna SLOCUM |
| Birth | 10 January 1680 | Windsor, Ct. | Brewster HIGLEY |
| Birth | 25 January 1680 | Billerica, Ma. | Nathaniel RICHARDSON |
| Birth | 29 January 1680 | Mendon, Ma. | Noah BARTLETT |
| Death | January 1680 | Dorchester, Ma. | Sarah HAMMON |
| Birth | 7 February 1680 | ? | Nicholas LITCHFIELD |
| Birth | 23 February 1680 | Sudbury, Ma. | Gershom BRIGHAM |
| Birth | 23 February 1680 | ? | Gershom BRIGHAM |
| Birth | 23 February 1680 | ? | Gershom BRIGHAM |
| Birth | 27 February 1680 | ? | Rachel HOBART |
| Birth | 28 February 1680 | Hatfield, Ma. | Mary FOOTE |
| Birth | 3 March 1680 | Springfield, Ma. | Samuel SIKES |
| Death | 14 March 1680 | College Point, N.Y. | William LAWRENCE |
| Death | 20 March 1680 | Taunton, Ma. | James BURT |
| Marriage | 25 March 1680 | ? | Samuel PITTS with Sarah BOBBITT |
| Birth | 27 March 1680 | Springfield, Ma. | Samuel SIKES |
| Birth | 29 March 1680 | Watertown, Ma. | Jonathan BALL |
| Birth | 1 April 1680 | ? | Sarah STODDARD |
| Death | 6 April 1680 | ? | John STODDARD |
| Birth | 10 April 1680 | Halifax, Ma. | Hannah STURTEVANT |
| Death | 18 April 1680 | Rehoboth, Ma. | Elizabeth BAUGH |
| Birth | 20 April 1680 | Watertown, Ma. | Samuel ROBINSON |
| Birth | 23 April 1680 | Hingham, Ma. | Josiah SPRAGUE |
| Birth | 29 April 1680 | Windsor, Ct. | Mary DRAKE |
| Death | April 1680 | ? | John GOODRICH |
| Birth | 1 May 1680 | Milford, Ct. | Mary GARNSEY |
| Death | 1 May 1680 | ? | Anna BULLARD |
| Birth | 2 May 1680 | ? | Samuel STOW |
| Death | 8 May 1680 | Wethersfield, Ct. | Dorothy RUSSELL |
| Birth | 14 May 1680 | Newbury, Ma. | Thomas HAYNES |
| Marriage | 14 May 1680 | Medfield, Ma. | Moses ADAMS with Mary FAIRBANKS |
| Birth | 18 May 1680 | Reading, Ma. | Jonas EATON |
| Birth | 20 May 1680 | ? | Mary HOLDEN |
| Birth | 21 May 1680 | Taunton, Ma. | Sarah LEONARD |
| Marriage | 25 May 1680 | ? | Isaac LEWIS with Mary DAVIS |
| Death | 28 May 1680 | Marlborough, Ma. | John HOWE |
| Birth | 8 June 1680 | Lexington, Ma. | Joseph SMITH |
| Marriage | 18 June 1680 | Sherborn, Ma. | Benoni LEARNARD with Mary FANNING |
| Birth | 24 June 1680 | Chelmsford, Ma. | Ephraim WARREN |
| Death | 28 June 1680 | Charlestown, Ma. | Richard KETTLE |
| Birth | 29 June 1680 | Westfield, Ma. | Mary NOBLE |
| Birth | 29 June 1680 | ? | Mary NOBLE |
| Birth | 6 July 1680 | ? | Nathan PECK |
| Birth | 10 July 1680 | Dorchester, Ma. | Sarah DAVENPORT |
| Birth | 10 July 1680 | ? | Sarah DAVENPORT |
| Birth | 11 July 1680 | Marshfield, Ma. | Chillingsworth FOSTER |
| Marriage | 13 July 1680 | ? | Jonathan THAYER with Elizabeth FRENCH |
| Death | 14 July 1680 | Watertown, Ma. | Hannah BARRON |
| Birth | 3 August 1680 | Sudbury, Ma. | Mary LOKER |
| Marriage | 4 August 1680 | ? | Thomas GILBERT with Abilene MARSHFIELD |
| Birth | 13 August 1680 | ? | James FALES |
| Birth | 13 August 1680 | Dedham, Ma. | James FALES |
| Death | 21 August 1680 | Middletowm, Ct. | Mary GRIGGS |
| Birth | 28 August 1680 | Watertown, Ma. | Joseph SANDERSON |
| Birth | 29 August 1680 | Watertown, Ma. | Hannah FISKE |
| Birth | 16 September 1680 | Ipswich, Ma. | John STARKWEATHER |
| Birth | 20 September 1680 | ? | Benjamin HOYT |
| Birth | 22 September 1680 | Swansea, Ma. | Jonathan BOSWORTH |
| Birth | 4 October 1680 | Duxbury, Ma. | Mercy WISWALL |
| Marriage | 17 October 1680 | Chelmsford, Ma. | Eli FOSTER with Judith KEYES |
| Death | 22 October 1680 | Andover, Ma. | Ann STRATTON |
| Death | 30 October 1680 | ? | Mary BURRAGE |
| Birth | 2 November 1680 | ? | Henry SPALDING |
| Death | 16 November 1680 | Reading, Ma. | Martha JENKIN |
| Birth | 20 November 1680 | Malden, Ma. | William SARGENT |
| Death | 29 November 1680 | Groton, Ma. | William LONGLEY |
| Marriage | 1 December 1680 | Little Compton, R.I. | Jonathan DAVENPORT with Hannah MAYNARD |
| Marriage | 8 December 1680 | ? | Daniel COOLEY with Elizabeth WOLCOTT |
| Death | 12 December 1680 | Concord, Ma. | Isaac HUNT |
| Birth | 12 December 1680 | Watertown, Ma. | Thomas GARFIELD |
| Birth | 12 December 1680 | ? | Thomas GARFIELD |
| Birth | 12 December 1680 | ? | Thomas GARFIELD |
| Marriage | 16 December 1680 | ? | Captain Peter GREENE with Elizabeth ARNOLD |
| Birth | 18 December 1680 | Northampton, Ma. | Samuel PHELPS |
| Birth | 22 December 1680 | Springfield, Ma. | Hannah STEBBINS |
| Birth | 26 December 1680 | West Hartford, Ct.t. | John WEBSTER |
| Death | 29 December 1680 | Groton, Ma. | Hannah LONGLEY |
| Death | December 1680 | Norwich, Ct. | Christyan ANDREWS |
| Birth | 1680 | Rochester, Ma. | Samuel MAXAM |
| Birth | 1680 | ? | Mercy HETT |
| Birth | 1680 | ? | Jane ANDERSON |
| Birth | about 1680 | ? | Phebe DORMAN |
| Marriage | about 1680 | Watertown, Ma. | John BEMIS with Mary HARRINGTON |
| Birth | 1680 | Simsbury, Ct. | John HOLCOMBE |
| Birth | about 1680 | Londonderry, Northern Ireland | William MOOR |
| Birth | about 1680 | ? | Ruth RAYMENT |
| Birth | 1680 | ? | Sarah BUCKNAM |
| Birth | 1680 | Brewster, Ma. | John WING |
| Death | 1680 | Groton, Ma. | William SANDERSON |
| Birth | about 1680 | ? | Catryntje HOUGHTALING |
| Death | 1680 | ? | Thomas JONES |
| Marriage | about 1680 | Hull, Ma. | John BOSWORTH with SARAH |
| Death | 1680 | ? | Elizabeth GODFREY |
| Birth | 1680 | Plymouth, Ma. | Abigail CHURCHILL |
| Death | 1680 | Cambridge, Ma. | Edward SHEPHERD |
| Birth | about 1680 | Groton, Ma. | Cornelius WHITNEY |
| Death | 1680 | Topsfield, Ma. | John BAKER |
| Birth | 1680 | Taunton, Ma. | Elizabeth HOSKINS |
| Birth | 1680 | ? | Priscilla WARNER |
| Death | 1680 | ? | Josiah WINSLOW |
| Birth | about 1680 | ? | Valentine Ii PRENTICE |
| Birth | about 1680 | Watertown, Ma. | John CADY |
| Birth | about 1680 | ? | HANNAH |
| Birth | 1680 | Groton, Ct. | Joseph CULVER |
| Death | 1680 | ? | Sarah DAVENPORT |
| Death | about 1680 | ? | Hestor NICHOLS |
| Birth | about 1680 | ? | Sarah HAYWARD |
| Birth | 1680 | Plymouth, Ma. | Sarah BARNES |
| Birth | about 1680 | Bridgewater, Ma. | John ALDEN |
| Marriage | 10 January 1681 | Marlborough, Ma. | Thomas RICE with Anna RICE |
| Death | 17 January 1681 | Hadley, Ma. | Samuel SMITH |
| Marriage | 19 January 1681 | Watertown, Ma. | Simon COOLIDGE with Priscilla ROGERS |
| Birth | 2 February 1681 | ? | Ebenezer DICKINSON |
| Death | 3 February 1681 | Haverhill, Ma. | Dorcas BOSWORTH |
| Death | 5 February 1681 | Kingston, R.I. | Sarah ODDING |
| Birth | 7 February 1681 | Rowley, Ma. | Judah CLARKE |
| Birth | 11 February 1681 | ? | Thomas LEARNARD |
| Birth | 27 February 1681 | ? | Ebenezer DUDLEY |
| Marriage | 1 March 1681 | ? | Joseph WHEELER with Mary POWERS |
| Birth | 1 March 1681 | Malden, Ma. | Mary LEWIS |
| Death | 3 March 1681 | Yarmouth, Ma. | Peter WORDEN |
| Death | 5 March 1681 | Concord, Ma. | BRIDGET |
| Birth | 6 March 1681 | Wells, Maine | Francis SAWYER |
| Birth | 7 March 1681 | Groton, Ma. | Daniel LAWRENCE |
| Birth | 14 March 1681 | Hatfield, Ma. | Sarah BELDING |
| Marriage | 10 April 1681 | ? | Joseph LOOMIS with Lydia DRAKE |
| Birth | 16 April 1681 | North Kingston, R.I. | Rev. Valentine WIGHTMAN |
| Death | 22 April 1681 | ? | Mary SHERWOOD |
| Birth | 6 May 1681 | Melville, N.Y. | Abigail BASSETT |
| Birth | 28 May 1681 | Watertown, Ma. | Joseph UNDERWOOD |
| Birth | 28 May 1681 | Bradford, Ma. | Thomas TENNEY |
| Birth | 29 May 1681 | Marlborough, Ma. | Daniel NEWTON |
| Death | 30 May 1681 | Ipswich, Ma. | Reginald FOSTER |
| Birth | 31 May 1681 | North Kingston, R.I. | William WEST |
| Death | 31 May 1681 | Stonington, Ct. | Mary GRANT |
| Birth | 2 June 1681 | Plymouth, Ma. | Mary FAUNCE |
| Birth | 3 June 1681 | ? | Martha LAWRENCE |
| Death | 7 June 1681 | Watertown, Ma. | Daniel SMITH |
| Birth | 20 June 1681 | ? | Rebecca COLTON |
| Birth | 20 June 1681 | Windsor, Ct. | Joseph BARNARD |
| Birth | 20 June 1681 | ? | Joseph BARNARD |
| Birth | 21 June 1681 | Providence, R.I. | Ebeneazer HERENDEEN |
| Birth | 21 June 1681 | ? | Ebeneazer HERENDEEN |
| Birth | 23 June 1681 | Roxbury, Ma. | Samuel DAVIS |
| Birth | 23 June 1681 | ? | Beriah BEMIS |
| Birth | 23 June 1681 | Watertown, Ma. | Beriah BEMIS |
| Death | 8 July 1681 | Charlestown, Ma. | Walter ALLEN |
| Death | 17 July 1681 | ? | Edward JACKSON |
| Death | 22 July 1681 | Reading, Ma. | Thomas KENDALL |
| Death | 2 August 1681 | Watertown, Ma. | Mary CASTLE |
| Birth | 11 August 1681 | Hadley, Ma. | Mary BARNARD |
| Birth | 14 August 1681 | ? | Deliverance RICE |
| Birth | 14 August 1681 | Sudbury, Ma. | Deliverance RICE |
| Birth | 16 August 1681 | Hadley, Ma. | Mary SMITH |
| Marriage | 29 August 1681 | ? | Jonathan ADAMS with Leah GOULD |
| Birth | 3 September 1681 | Beverly, Ma. | Israel BALCH |
| Birth | 10 September 1681 | Sandwich, Ma. | Hannah PERRY |
| Birth | 10 September 1681 | ? | Hannah PERRY |
| Birth | 17 September 1681 | Stow, Ma. | Thomas WHITNEY |
| Birth | 18 September 1681 | ? | Elizabeth PARKHURST |
| Birth | September 1681 | Salem, Ma. | Peter TWISS |
| Death | 4 October 1681 | Newport, R.I. | Robert (Sir Baronet) CARR |
| Birth | 4 October 1681 | ? | Sarah BIGELOW |
| Death | 7 October 1681 | Windsor, Ct. | Elizabeth ROGERS |
| Death | 7 October 1681 | ? | Elizabeth ROGERS |
| Birth | 8 October 1681 | Springfield, Ma. | Benjamin COOLEY |
| Birth | 10 October 1681 | Cambridge, Ma. | Hannah OLDHAM |
| Birth | 11 October 1681 | Cambridge, Ma. | Amos GATES |
| Birth | 15 October 1681 | ? | Ruth WARREN |
| Birth | 16 October 1681 | ? | William CARR |
| Death | 18 October 1681 | Milford, Ct. | Thomas SANFORD |
| Marriage | 18 October 1681 | Watertown, Ma. | Daniel HARRINGTON with Sarah WHITNEY |
| Death | 19 October 1681 | Springfield, Ma. | Mary DRAKE |
| Birth | 20 October 1681 | ? | Samuel GORE |
| Birth | 20 October 1681 | Roxbury, Ma. | Samuel GORE |
| Birth | 20 October 1681 | ? | Samuel GORE |
| Death | 31 October 1681 | Bridgewater, Ma. | John CARY |
| Birth | 3 November 1681 | Springfield, Ma. | Thomas GILBERT |
| Birth | 3 November 1681 | ? | Thomas GILBERT |
| Birth | 3 November 1681 | ? | Thomas GILBERT |
| Birth | 9 November 1681 | New London, Ct. | Jonathan AVERY |
| Death | 16 November 1681 | Sudbury, Ma. | Thomas RICE |
| Birth | 25 November 1681 | Woburn, Ma. | Samuel PEIRCE |
| Marriage | 25 November 1681 | Reading, Ma. | James PIKE with Hannah CUTLER |
| Birth | 26 November 1681 | Medfield, Ma. | Deborah MORSE |
| Marriage | 30 November 1681 | Concord, Ma. | Eliphalet FOX with Mary STONE |
| Marriage | 30 November 1681 | ? | John MARSHALL with DAMARIS |
| Death | 6 December 1681 | Watertown, Ma. | Martha FOSDICK |
| Birth | 10 December 1681 | Dedham, Ma. | Joseph WIGHT |
| Birth | 10 December 1681 | Dorchester, Ma. | Thomas DAVENPORT |
| Birth | 12 December 1681 | Watertown, Ma. | Sarah GALE |
| Death | 13 December 1681 | ? | Mathew BECKWITH |
| Marriage | 14 December 1681 | ? | Samuel AYRES with Mary JOHNSON |
| Death | 15 December 1681 | Berwick, Maine | Thomas SPENCER |
| Marriage | 16 December 1681 | ? | Abraham TAYLOR with Mary WHITTAKER |
| Death | 16 December 1681 | Windsor, Ct. | Mathew GRANT |
| Death | 20 December 1681 | ? | John PRESCOTT |
| Death | 20 December 1681 | Lancaster, Ma. | John PRESCOTT |
| Birth | 1681 | ? | Anne DARBY |
| Birth | 1681 | ? | Jonathan WHITNEY |
| Death | 1681 | Watertown, Ma. | Mary CASTLE |
| Marriage | 1681 | ? | Nathaniel WILSON with Hannah JACKSON |
| Death | 1681 | ? | Susanna BRADFORD |
| Death | 1681 | Chelmsford, Ma. | Priscilla UNDERWOOD |
| Birth | 1681 | Plymouth, Ma. | Nehemiah STURTEVANT |
| Birth | 1681 | England | John KING |
| Marriage | 1681 | Dedham, Ma. | Abraham WHEELER with Tabitha STONE |
| Death | after 1681 | Salem, Ma. | John LONGLEY |
| Birth | 1681 | ? | Ebenezer MORTON |
| Death | 1681 | Billerica, Ma. | William FRENCH |
| Birth | 1681 | ? | Walsingham CHILSON |
| Birth | about 1681 | Dumfries, Scotland | Mathew PATRICK |
| Death | 1681 | ? | Elizabeth HAWKS |
| Birth | 1681 | Chelmsford, Ma. | Esther FLETCHER |
| Birth | 1681 | Braintree, Ma. | Samuel ALDRICH |
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